These are our 10 most cited Emergency and Critical Care reviews for 2021.

Congratulations to the author teams who produced these reviews, and to the editorial teams who supported their production! Many of these reviews have been cited in evidence-based clinical guidelines. 

Pharmacological agents for adults with acute respiratory distress syndrome

Immunonutrition for acute respiratory distress syndrome (ARDS) in adults

Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit

Anticoagulants for people hospitalised with COVID-19

Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults

Pharmacological interventions for the treatment of delirium in critically ill adults

Corticosteroids for treating sepsis in children and adults

Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children

Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without supplemental parenteral nutrition in critically ill adults

Chest ultrasonography versus supine chest radiography for diagnosis of pneumothorax in trauma patients in the emergency department