Our reviews

Full list:

By subtopic:

Anaphylaxis (4)
Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community
Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock
Glucocorticoids for the treatment of anaphylaxis
H1-antihistamines for the treatment of anaphylaxis with and without shock
Cardiac arrest (7)
Community first responders for out-of-hospital cardiac arrest in adults and children
Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non-asphyxial out-of-hospital cardiac arrest
Hypothermia for neuroprotection in adults after cardiac arrest
Family presence during resuscitation
Cardiopulmonary resuscitation (CPR) plus delayed defibrillation versus immediate defibrillation for out-of-hospital cardiac arrest
Pre-hospital versus in-hospital initiation of cooling for survival and neuroprotection after out-of-hospital cardiac arrest
Hypothermia for neuroprotection in children after cardiopulmonary arrest
Coagulation and bleed management (6)
Antithrombin III for critically ill patients
Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding
Anticoagulants for people hospitalised with COVID-19
Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients
Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non-bleeding patients
Fibrinogen concentrate in bleeding patients
Haemodynamic management (15)
Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children
Central venous access sites for the prevention of venous thrombosis, stenosis and infection
Catheter impregnation, coating or bonding for reducing central venous catheter-related infections in adults
Central venous catheter (CVC) removal for patients of all ages with candidaemia
Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock
Heparin versus normal saline for patency of arterial lines
Interventions for restoring patency of occluded central venous catheter lumens
Optimal timing for intravascular administration set replacement
Pulmonary artery catheters for adult patients in intensive care
Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients
Ultrasound guidance versus anatomical landmarks for internal jugular vein catheterization
Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization
Ultrasound-guided arterial cannulation in the paediatric population
Vascular access specialist teams for device insertion and prevention of failure
Vasopressors for hypotensive shock
High altitude illness (4)
Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions
Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs
Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs
Interventions for treating acute high altitude illness
Hyperbaric therapy (2)
Recompression and adjunctive therapy for decompression illness
Adjunctive hyperbaric oxygen for necrotizing fasciitis
Miscellaneous (7)
Interleukin-1 blocking agents for treating COVID-19
Harms of off-label erythropoiesis-stimulating agents for critically ill people
Interventions for the prevention and treatment of COVID-19: a living mapping of research and living network meta-analysis (protocol stage)
Interventions for the treatment of COVID-19: a living network meta-analysis (protocol stage)
Drugs for the treatment of nausea and vomiting in adults in the emergency department setting
Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death
Care bundles for improving outcomes in patients with COVID-19 or related conditions in intensive care – a rapid scoping review
Nutrition and metabolic management (8)
Enteral versus parenteral nutrition and enteral versus a combination of enteral and parenteral nutrition for adults in the intensive care unit
Prescribed hypocaloric nutrition support for critically-ill adults
Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without supplemental parenteral nutrition in critically ill adults
Glutamine supplementation for critically ill adults
Immunonutrition for acute respiratory distress syndrome (ARDS) in adults
Nutritional support for critically ill children
Post-pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill adults
Selenium supplementation for critically ill adults
Positioning of critically ill individuals (2)
Lateral positioning for critically ill adult patients
Prone position for acute respiratory failure in adults
Rehabilitation, mobilization and exercise (4)
Cognitive training for prevention of cognitive impairment in adult intensive care unit (ICU) patients (protocol stage)
Diaries for recovery from critical illness
Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit
Exercise rehabilitation following intensive care unit discharge for recovery from critical illness
Respiratory Management (39)
Lung protective ventilation strategy for the acute respiratory distress syndrome
Aerosolized prostacyclins for acute respiratory distress syndrome (ARDS)
Oxygen targets in the intensive care unit during mechanical ventilation for acute respiratory distress syndrome: a rapid review
Closed tracheal suction systems versus open tracheal suction systems for mechanically ventilated adult patients
Percutaneous techniques versus surgical techniques for tracheostomy
Pressure-controlled versus volume-controlled ventilation for acute respiratory failure due to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS)
Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children
Pharmacological agents for adults with acute respiratory distress syndrome
High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome
Extracorporeal membrane oxygenation for critically ill adults
Heat and moisture exchangers versus heated humidifiers for mechanically ventilated adults and children
High-flow nasal cannula therapy for respiratory support in children
High-flow nasal cannulae for respiratory support in adult intensive care patients
High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome
Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit
Chest ultrasonography versus supine chest radiography for diagnosis of pneumothorax in trauma patients in the emergency department
Oxygenation during the apnoeic phase preceding intubation in adults in prehospital, emergency department, intensive care and operating theatre environments
Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adults
Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients
Neuromuscular blocking agents for acute respiratory distress syndrome (protocol stage)
Partial liquid ventilation for preventing death and morbidity in adults with acute lung injury and acute respiratory distress syndrome
Conservative versus interventional management for primary spontaneous pneumothorax in adults
Partial liquid ventilation for the prevention of mortality and morbidity in paediatric acute lung injury and acute respiratory distress syndrome
Peripheral venous blood gas analysis versus arterial blood gas analysis for the diagnosis of respiratory failure and metabolic disturbance in adults (protocol stage)
Cough augmentation techniques for extubation or weaning critically ill patients from mechanical ventilation
Prone position for management of respiratory failure in non-intubated adults (protocol stage)
Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation
Simple aspiration versus intercostal tube drainage for primary spontaneous pneumothorax in adults
Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults
Strategies to help adults with a breathing tube to communicate
Protocolized versus non-protocolized weaning for reducing the duration of invasive mechanical ventilation in critically ill paediatric patients
Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients
Early versus late tracheostomy for critically ill patients
Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units
Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults
Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure
Automated weaning and spontaneous breathing trial systems versus non-automated weaning strategies for discontinuation time in invasively ventilated postoperative adults
Factors that impact on the use of mechanical ventilation weaning protocols in critically ill adults and children: a qualitative evidence-synthesis
Pressure support versus T-tube for weaning from mechanical ventilation in adults
Sedation, sleep promotion, delirium (16)
Anaesthetic and sedative agents used for electrical cardioversion
BIS monitoring versus clinical assessment for sedation in mechanically ventilated adults in the intensive care unit and its impact on clinical outcomes and resource utilization
The use of propofol for procedural sedation in emergency departments
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients
Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation
Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients
Interventions for preventing intensive care unit delirium in adults
Ketamine and propofol in combination for adult procedural sedation and analgesia in the emergency department (protocol stage)
Pharmacological interventions for the treatment of delirium in critically ill adults
Melatonin for the promotion of sleep in adults in the intensive care unit
Midazolam for sedation before procedures
Music interventions for mechanically ventilated patients
Non-pharmacological interventions for sleep promotion in the intensive care unit
Propofol for the promotion of sleep in adults in the intensive care unit
Protocol-directed sedation versus non-protocol-directed sedation in mechanically ventilated intensive care adults and children
Capnography versus standard monitoring for emergency department procedural sedation and analgesia
Septic shock management (13)
Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis
De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock
Antifungal agents for preventing fungal infections in non-neutropenic critically ill patients
Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients
Corticosteroids for treating sepsis in children and adults
High-volume haemofiltration for sepsis in adults
Higher versus lower blood pressure targets in adults with shock (protocol stage)
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
N-acetylcysteine for sepsis and systemic inflammatory response in adults
Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults
Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock
Procalcitonin, C-reactive protein, and presepsin for the diagnosis of sepsis in adults and children (protocol stage)
Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in adults

New and Updated (in the latest issue of the CLib):